Orientation of Integrins at Leading Edge of Migrating T Cell (IMAGE)

Marine Biological Laboratory

Orientation of Integrins at Leading Edge of Migrating T Cell

Caption

The images show the orientation of integrins (yellow and green lines) at the leading edge (red lines) of a migrating white blood cell and within the focal adhesions (magenta lines) of a migrating fibroblast, analyzed using the instantaneous fluorescence polarization microscope developed at MBL. Circular histograms show that integrins are consistently oriented relative to the direction of migration in both cell types.

Credit

(white blood cell) Pontus Nordenfelt, Travis Moore, Shalin Mehta; (fibroblast) Vinay Swaminathan, Shalin Mehta.

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