(IMAGE) Kumamoto University Caption Kanki, et.al. demonstrate that angiogenesis essential immediate-early genes are silent with canonical PRC-brake in inert endothelium. In a short time, VEGF unlocks the transcription of these genes through bivalent status on the gene loci with PTIP/NFAT, MLL3/4 and noncanonical PRC1.3 accumulation. Credit Dr. Takashi Minami Usage Restrictions Credit must be given to the creator. License CC BY Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.