Engineered Protein (IMAGE)
Caption
Structure of an SEB molecule (blue) in complex with the variable region (grey with colored loops) of the T-cell receptor protein. Various amino acid residues in the loops (especially the residues colored red) were mutated to generate a protein that bound SEB with over one million-fold higher binding than the original. Soluble forms of this mutant protein were capable of neutralizing SEB in rabbit models.
Credit
Image courtesy of David M. Kranz
Usage Restrictions
Contact David M. Kranz for permission to use this image: 217 - 244-2821; d-kranz@uiuc.edu
License
Licensed content