Fig.2 Suppression of autophagy in adipose tissue decreases hepatic steatosis and ketogenesis during fasting. (IMAGE)

The University of Osaka

Fig.2 Suppression of autophagy in adipose tissue decreases hepatic steatosis and ketogenesis during fasting.

Caption

(Left: Mouse liver) The panel shows the Hematoxylin-Eosin staining in the liver from 24-h-fasted mice. Control mice exhibited a significant accumulation of lipid droplets, whereas this accumulation was reduced in adipose-specific Atg5 knockout mice in which autophagy was suppressed. (Right: Blood ketone body level) The panel shows the blood ketone body levels in fed or 24-h-fasted mice. Control mice exhibited a fasting-induced increase in blood ketone body levels, whereas this increase was impaired in adipose-specific Atg5 knockout mice in which autophagy was suppressed. This result indicates that adipose autophagy is required for ketone body production in the liver.

Credit

Tadashi Yamamuro et al.

Usage Restrictions

Credit must be given to the creator.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.