Insulin/IGF-1 Signaling and Amino Acid Uptake by Lung Tumor Cells (IMAGE)
Caption
This heat map shows levels of amino acids, the building blocks of protein, inside six non-small-cell lung tumor cell lines derived from Kras-mutant mice. Essential amino acids, which must be acquired from the diet, are listed in bold. At left, indicated in red, tumor cells from mice that carry the Irs1/Irs2 gene have higher levels of amino acids. At right are tumor cells from mice that have lost Irs1/Irs2, and consequently, insulin/IGF-1 signaling. As a result, these cells take up fewer amino acids and have strikingly lower levels, as shown in blue, and try to maintain growth by breaking down their own proteins to get amino acids.
Credit
Clare (He) Xu, PhD, Boston Children's Hospital
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