UMBC Cancer Research (IMAGE) University of Maryland Baltimore County Caption Danielle Schmitt (l) and Songon An (r) study signaling pathways in cancer cells. Their new paper in PLOS ONE found that the PDK1 pathway, known to be active in metastatic cells, regulates the formation of a three-protein complex that facilitates purine biosynthesis. This finding encourages further work on the role of purine biosynthesis and other signaling pathways in metastasis, which An will pursue with a UMBC colleague in biochemical engineering. Credit Marlayna Demond for UMBC Usage Restrictions include credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.