Jamming the Proteasome (IMAGE)

California Institute of Technology

Jamming the Proteasome

Caption

A dysfunctional protein (green) gets tagged for destruction with a ubiquitin chain (gray). Ubiquitin guides the bad protein to the proteasome for destruction, and is snipped off--a process called deubiquitination. A new cancer treatment would inhibit this vital part of the process, causing cancer cells to fill up with dysfunctional proteins and self-destruct.

Credit

Courtesy of the Deshaies laboratory

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