Development of iTango Platform (IMAGE) Max Planck Florida Institute for Neuroscience Caption This is a graphical illustration of the iTango system. DRD2-V2 tail (C-terminus of V2 vasopression receptor)-CIBN-AsLOV2-tTA functions as a main platform. Two more modules cooperate together to cleave TEVseq by reacting to either light or ligand. DRD2 activation by an agonist will lead to beta-Arrestin2-TEV-N fusion protein translocate and bind to V2 tail. The other TEV-C will be recruited by blue light via CRY2PHRCIBN binding. When all iTango modules combine, released tTA will translocate to the nucleus to cause gene expression. Credit Max Planck Florida Institute for Neuroscience Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.