Cancer-Metastasizer SNAI2 Gets Tagged for Recycling (IMAGE)

Princeton University

Cancer-Metastasizer SNAI2 Gets Tagged for Recycling

Caption

SNAI2 (pronounced snail-too) helps cancers metastasize and hide from treatment, but Kang and his team have found two keys to controlling it: A "recycler" named ASB13 that tags SNAI2 for shredding, and a "dub" named USP20 that removes those tags. While SNAI2 is notoriously hard to attack directly, ASB13 and USP20 are affected by medications, providing a new path to treatment.

Credit

Illustration by Yibin Kang

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