Figure 2. OCM of Alzheimer's disease mouse model. (IMAGE)

Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS

Figure 2. OCM of Alzheimer's disease mouse model.

Caption

a, The 5xFAD transgenic mouse has distinct highly scattering clusters (red arrows) and wide hyporeflective regions (yellow asterisk), depicted both in sagittal (left panel) and en face planes (right panels). Depth color-coded en face images of myelinated axons and corresponding grayscale images illustrate intact myeloarchitecture in the WT littermate (b-c), while suggesting demyelination in deeper layers of the AD mouse (d-e). Taken together, OCM depicts a higher incidence of abnormal findings in layers IV-VI, consistent with the higher disease burden in these layers. Scalebars are 0.1 mm.

Credit

by Jun Zhu, Hercules Rezende Freitas, Izumi Maezawa, Lee-way Jin, and Vivek J. Srinivasan

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