Figure 3. Schematic depicting the key findings of the study. (IMAGE)

Institute for Basic Science

Figure 3. Schematic depicting the key findings of the study.

Caption

On the left, normal trans-synaptic interaction of presynaptic PTPδ and postsynaptic IL1-RAPL1 in the synapse, which critically requires the meA in PTPδ (red triangle). In the middle, disruption of the trans-synaptic PTPδ-IL1RAPL1 interaction through the loss of the whole PTPδ or of the meA. On the right, the loss of the trans-synaptic PTPδ-IL1RAPL1 interaction leads to the loss of synaptic structure and function along with altered brain functions manifested by decreased sleep and abnormal sleep rhythms as seen in delta waves during non-REM deep sleep.

Credit

IBS

Usage Restrictions

Please indicate the credit.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.