Where PTEN is Abundant, so is Ipo11 (IMAGE)

Cold Spring Harbor Laboratory

Where PTEN is Abundant, so is Ipo11

Caption

Cross sections of prostate tissue in healthy mice (top row) and mice in which cancer is beginning to develop (bottom row). Healthy tissue shows regular structures and empty spaces (white in the far left image) called lumen. Cancerous tissue is less organized, and is more densely populated with cells, which are proliferating abnormally. Insets show consistently that when Ipo11 is abundant, so is PTEN tumor-suppressing protein; when PTEN levels are low, so is the protein Importin 11 (Ipo11). Its presence of absence may be a useful diagnostic and therapeutic marker in prostate biopsies.

Credit

Trotman lab, CSHL

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