KRAS Cytoplasm (IMAGE)

Cold Spring Harbor Laboratory

KRAS Cytoplasm

Caption

When KRAS (red) is modified to stay in the cytoplasm or center of the cell, as seen in these pancreas cells, the protein does not promote cell division. In pancreatic cancer cells, a mutant form of KRAS stays close to the cell's outer layer and interacts with nearby proteins to cause the cells to divide far too much.

Credit

Derek Cheng/Tuveson lab/CSHL, 2021

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