Structural Analysis of Broadly Neutralizing Antibody 8ANC195 (IMAGE)

California Institute of Technology

Structural Analysis of Broadly Neutralizing Antibody 8ANC195

Caption

Broadly neutralizing antibodies to HIV-1 envelope glycoprotein are being evaluated as therapeutics to prevent or treat HIV-1 infection. Structural analysis of one such antibody, 8ANC195, revealed a new conformation of the envelope protein. The image shows the X-ray crystal structure of 8ANC195 in complex with the gp120 subunit of the envelope protein. The background shows schematic representations of HIV-1 virus particles studded with envelope proteins being recognized by 8ANC195 antibodies.

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Louise Scharf/Caltech

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