8ANC195 Partially Closes the Envelope Trimer (IMAGE)

California Institute of Technology

8ANC195 Partially Closes the Envelope Trimer

Caption

Structural analysis of the patient-derived antibody 8ANC195 uncovers a previously-unseen conformation of the HIV-1 envelope protein (Env) and suggests that 8ANC195 partially closes the envelope trimer when it is engaged with the host receptor on human cells. The closed (top panel) and open (bottom panel) structures of HIV-1 Env (consisting of gp120 and gp41 subunits, blue) are shown as surfaces. The antibody (8ANC195, pink) and host receptor (CD4, yellow) are shown as ribbon diagrams.

Credit

Louise Scharf/Caltech

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