Mutations in Amino Acids in the CA Domain Change the Gag Structure in the Immature Virion (IMAGE)

U.S. National Science Foundation

Mutations in Amino Acids in the CA Domain Change the Gag Structure in the Immature Virion

Caption

Advanced computation sheds light on HIV's behavior, opening up new research directions to battle this global disease. Key mutations in specific amino acids in the CA domain change the Gag structure in the immature virion, perhaps altering the HIV-1 maturation pathway. The domains with the highest degree of structure are shown with yellow dots.

Credit

Gregory A. Voth, University of Chicago

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