Fig. 2 MondoA counteracts cellular senescence in aging and ischemic AKI in humans (IMAGE)

The University of Osaka

Fig. 2 MondoA counteracts cellular senescence in aging and ischemic AKI in humans

Caption

Immunostaining images of MondoA and the senescence marker p21 in kidney biopsy samples from young and aged individuals, and from ischemic acute kidney injury (AKI) patients. In kidneys from aged individuals and ischemic AKI patients, the number of p21-positive cells (right, brown) was higher compared with young individuals, and this was accompanied by decreased expression of MondoA (left, brown) in the nucleus (purple).

Credit

2022 Yamamoto-Imoto et al. Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis. Cell Reports

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