PTP1B Inhibitor Reduces HER2-Positive Tumors, Metastases (IMAGE)

Cold Spring Harbor Laboratory

PTP1B Inhibitor Reduces HER2-Positive Tumors, Metastases

Caption

The candidate drug MSI-1436 (trodusquemine) inhibits HER2-positive tumor formation and metastasis through its inhibition of the enzyme PTP1B. Here, its effect on HER2-positive lung metastasis is shown: image at far left is untreated; dark areas are tumor metastases. The drug at two doses is shown to clear the metastatic lesions (dosage in center image is half that in right image).

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Tonks lab/Cold Spring Harbor Laboratory

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