Binding Sites on PTP1B Enzyme (IMAGE)

Cold Spring Harbor Laboratory

Binding Sites on PTP1B Enzyme

Caption

The PTP1B inhibitor MSI-1436 (trodusquemine) binds at two sites on the enzyme. The principal allosteric site, a weaker alternate site, and the previously recognized main, or catalytic, binding site are shown in this rendering.

Credit

Tonks lab/Cold Spring Harbor Laboratory

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