Pulmonary Phenotypes of Low-Mortality Mice (IMAGE)

Kumamoto University

Pulmonary Phenotypes of Low-Mortality Mice

Caption

Crossing of C3B6 and C57BL/6 mouse lines results in low-mortality βENaC-Tg mice. A multifaceted evaluation of the pulmonary pathology shows the new mouse line to have various obstructive pulmonary disease symptoms, such as high mucus retention. The FEV% over 0.1s is a meaningful parameter since a similar measure, FEV% over 1.0s, is used to assess disease progression in humans. Adapted from Shuto, et al., 2016 (http://www.nature.com/articles/srep39305)

Credit

Associate Professor Tsuyoshi Shuto

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