<I>Science Signaling</I> (IMAGE)

Children's National Hospital

<I>Science Signaling</I>

Caption

This week features a Research Article that describes the pathway by which mitochondria transduce the increase in cytosolic Ca2+ caused by plasma membrane injury into a ROS-dependent repair response (see also the associated Focus). The image shows ROS production and actin polymerization as detected by fluorescent reporters near a plasma membrane injury site in a skeletal myofiber in the intact bicep of an experimental model.

Credit

Adam Horn and Jyoti Jaiswal, M.S.C., Ph.D. Children's National Health System and The George Washington University School of Medicine and Health Sciences

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