Figure 3. (IMAGE)

The University of Osaka

Figure 3.

Caption

By using our method, a fluoroalkene mimic of a widely used antihyperlipidemic drug, atorvastatin, was synthesized in three steps from easily available bromopyrrole. Evaluation of the HMG-CoA reductase inhibitory effect of the mimic compound demonstrated that the replacement of the amide moiety to the fluoroalkene structure did not significantly affect the activity of the original compound.

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©2017 Osaka University, RIKEN, and Tokyo Medical and Dental University

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