Single-Molecule Imaging of DNA Repair (VIDEO)

University of Pittsburgh

Caption

What you're seeing here is two individual molecules working together to fix a "tightrope" of damaged DNA, stretched between two silica beads. Damage detector UV-DDB (red) and repair molecule APE1 (green) zip to the spot that needs fixing. The video is slowed down to 1/20 normal speed to show how the two molecules cooperate (yellow indicates overlap).

Credit

Jang et al. (2019) Nature Structural and Molecular Biology

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