Schematic Diagram of the Angiogenic Signaling Modulating Mechanism through VASH1/ΔY-tubulin. (IMAGE)

_Tokyo Medical and Dental University

Schematic Diagram of the Angiogenic Signaling Modulating Mechanism through VASH1/ΔY-tubulin.

Caption

VASH1 exerts anti-angiogenic effects through the inhibition of receptor endocytosis by ?Y-tubulin increases. VEGF and FGF2 induce endocytosis of their own receptors, VEGFR2 and FGFR1, respectively, along MTs. This is important for VEGF (FGF2)-signaling activation and pro-angiogenic effects. VASH1 induces the generation of ?Y-tubulin-rich MTs (excessive ?Y-tubulin levels), leading to suppression of retrograde trafficking, such as receptor endocytosis. Thereby VASH1 inhibits VEGF/FGF2-induced VEGFR2/FGFR1 endocytosis and subsequent signaling activation, acceleration of EC migration, and angiogenesis.

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Department of Biochemistry,TMDU

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