3D Tubulogenesis (IMAGE)

Kanazawa University

3D Tubulogenesis

Caption

Epithelial tubulogenesis (blanching duct formation) is critical for functional tissue architecture in several organs, including kidney, mammary gland, lung, and bile duct. In the culture of normal human kidney tubular cells in 3D collagen gel, artificial HGF/aMD5-PEG11, as well as HGF, dynamically induce tubulogenesis. This biological activity is unique to HGF-MET receptor pathway. Therefore, artificial peptide HGF capable of activating MET in a comparable ability to HGF may be applicable to regeneration-based medicine as a new biological drug candidate.

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Kanazawa University

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