Wipi3 is required for the maintenance of brain cells via alternative autophagy (IMAGE)

_Tokyo Medical and Dental University

Wipi3 is required for the maintenance of brain cells via alternative autophagy

Caption

Wipi3 is translocated from the cytosol to the trans-Golgi, and manipulates the trans-Golgi membrane to generate autophagic vacuoles. In vivo, Wipi3-dependent alternative autophagy degrades excess ceruloplasmin, and prevents abnormal iron deposition in brain cells.

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Department of Pathological Cell Biology,TMDU

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