Neurodegeneration (2 of 2) (IMAGE)

University of Manchester

Neurodegeneration (2 of 2)

Caption

Pictured is the cerebellar region of a mouse brain labelled for the Golgi apparatus (red), DNA (blue) and Purkinje neutrosn (green). The Purkinje neurons have an elaborate Golgi, as first observed by Camillo Golgi when he discovered the organelle in 1898. Liu et al have shown that Golgi positioning and organisational are disrupted in mice lacking the Golgi protein GM130, which leads to death of Purkinje neurons and ataxia.

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The University of Manchester/Martin Lowe

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