AAV-PHP.eB Non-Invasively Delivers Transgenes under the Control of Different Gene Regulatory Element (IMAGE)

California Institute of Technology

AAV-PHP.eB Non-Invasively Delivers Transgenes under the Control of Different Gene Regulatory Element

Caption

The engineered viral vector AAV-PHP.eB carrying reporter genes controlled by different gene regulatory elements enables expression of a gene of interest in specific cell populations across the adult mouse brain. Top: green fluorescent protein expression from a Purkinje cell-specific promoter; bottom: a red fluorescent protein driven by a forebrain inhibitory neuron-restricted promoter.

Credit

Chan et al., Gradinaru Lab; Nature Neuroscience

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