A Novel Mechanism Underlying Heart Failure Development (IMAGE)

Kumamoto University

A Novel Mechanism Underlying Heart Failure Development

Caption

Aging and stress, such as high blood pressure, are causes of heart failure. These factors increase ANGPTL2 production and secretion in cardiac muscle cells. Excessively secreted ANGPTL2 impairs important cardiac muscle cell functions, such as intracellular calcium concentration regulation and energy production, that help maintain the contractile force of the heart and promotes the development of heart failure.

Credit

Professor Yuichi Oike

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