New Gene Therapy Suppresses ANGPTL2 In Cardiac Muscle Cells, Preventing Heart Failure Progression In (IMAGE)
Caption
In mice treated with a virus that does not affect ANGPTL2 production in cardiac muscle cells (green), the rate of decrease in contractile force of the heart was 13 percent from virus injection. On the other hand, in mice treated with a virus that can suppress ANGPTL2 production in cardiac muscle cells (blue or red), a reduction in the contractile force was prevented. In particular, treatment with a high-dose of the virus more effectively suppressed progression of heart failure (red), producing a rate of decrease in the contractile force of 6 percent. It is expected that this new gene therapy will become a novel therapeutic strategy for heart failure.
Credit
Professor Yuichi Oike
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