Model of Integration of TrkB and Calcium Signals to Induce PKCα Activation in Paired and Unpaired (IMAGE)

Max Planck Florida Institute for Neuroscience

Model of Integration of TrkB and Calcium Signals to Induce PKCα Activation in Paired and Unpaired

Caption

A subthreshold stimulus that was unable to induce plasticity was given alone (unpaired) or after a nearby plasticity-inducing stimulation (paired). Unpaired, the stimulus could not activate PKCα or induce plasticity. However, when paired with recent plasticity in a nearby spine, which induces a long-lasting, spreading TrkB activity, this same subthreshold stimulus led to PKCα activation and plasticity.

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Max Planck Florida Institute for Neuroscience

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