Schematic of the Interferon-Stimulated Memory Effect (IMAGE)

Hokkaido University

Schematic of the Interferon-Stimulated Memory Effect

Caption

This is a schematic of the interferon-stimulated memory effect. Untreated cells (naïve cells), upon exposure to interferons, read memory interferon-stimulated genes (ISGs) that are wrapped around standard histones (yellow cylinders). This leads to their becoming 'pretreated cells' and the swapping of the standard histones for variants (green cylinders) as well as the histones' modification (pink and blue pins). At subsequent interferon exposures, reading of ISGs is stronger and commences more quickly.

Credit

Hokkaido University

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