Changes in Brain Connectivity (IMAGE) Washington University School of Medicine Caption Researchers identified functional differences in the brains of APOE4-positive and APOE4-negative people. Red indicates increased connectivity among regions at rest while blue shows decreased connectivity. Credit Reprinted with permission: Sheline, et al. The <i>Journal of Neuroscience</i> 2010 Usage Restrictions For reporters, free use with appropriate credit line. All others, please contact The Journal of Neuroscience. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.