Prolonging Transplant Survival by Turning on DEPTOR (IMAGE)
Caption
When mice received an immunosuppressive agent (anti-CD154), their heart transplants survived for up to 30 days (blue line). But when mice also had the DEPTOR gene turned on, all recipients still had living grafts 100 days post-transplant (green line). In "knock-in" mice that had the DEPTOR gene turned on, heart transplants survived an average of 35 days, even without the immunosuppressant.
Credit
Johannes Wedel, Boston Children's Hospital
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