Switching Side in Cancer (1 of 2) (IMAGE)

Cold Spring Harbor Laboratory

Switching Side in Cancer (1 of 2)

Caption

The protein p53-psi, a variant of the well-known anti-cancer guardian protein p53, can reprogram cells to "switch sides" and acquire pro-metastatic features. Pro-metastatic cells naturally expressing p53-psi are seen in LEFT panel. On RIGHT, when p53-psi is silenced, these cells reacquire the characteristics of non-metastatic cells.

Credit

Sordella lab, Cold Spring Harbor Laboratory

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