AMPK in Cell Nucleus (IMAGE) University of Pennsylvania School of Medicine Caption In the cell nucleus, AMPK works at the DNA level to add a phosphate to histones to control gene expression. Credit David Bungard, PhD, University of Pennsylvania School of Medicine Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.