Deguelin Causes Mitochondrial Networks to Fragment (IMAGE)
Caption
Left: nucleus (N) of a healthy cell, surrounded by networks of mitochondria, whose networks form spaghetti-like strands just outside the nucleus. Right: After treatment with mitochondrial inhibitor deguelin, mitochondria have fragmented and are now separated in the space between two cellular nuclei. Administered when glucose is low, such inhibitors effectively induce cancer cells to eat themselves to death. Normal cells survive.
Credit
Trotman Lab, CSHL
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