Treatment with MAPK Inhibitor Only Kills Some Colon Cancer Cells in Mice (IMAGE)

Rockefeller University Press

Treatment with MAPK Inhibitor Only Kills Some Colon Cancer Cells in Mice

Caption

Human colon cancer cells injected into mice form tumors (left) consisting of both MAPK-active cells (green) and NOTCH-active cells (red). Treatment with the MAPK inhibitor selumetinib results in tumors consisting of NOTCH-active cells only (center), but after treatment is stopped, the NOTCH-active cells give rise to new MAPK-active cells, restoring the tumors' original composition (right).

Credit

Schmidt et al., 2018

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