Human embryo development without OCT4 (VIDEO) The Francis Crick Institute This video is under embargo. Please login to access this video. To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Caption This is a time lapse video showing human embryo development in embryos that have been edited so they do not produce the OCT4 protein. These embryos fail to form a stable blastocyst, showing that OCT4 is essential for blastocyst development. Credit Dr Kathy Niakan/Nature Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.