Epigenomic Signature (IMAGE)

NIH/National Institute of Environmental Health Sciences

Epigenomic Signature

Caption

An epigenomic signature can be made on the genome in two ways, both of which play a role in turning genes off or on. The first occurs when chemical tags called methyl groups are attached to a DNA molecule directly (DNA methylation). The second occurs when a variety of chemical tags attach to the tails of histone proteins that package DNA (histone modifications).

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Image courtesy of John Stamatoyannopoulos and Rae Senarighi

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