Graphical Abstract (IMAGE)

UT Southwestern Medical Center

Graphical Abstract

Caption

In the native state, DnaJB8 chaperone forms soluble oligomers in which the J domain (JD, red) is engaged in electrostatic interactions with the C-terminal domain (CTD, green) and thus not available for Hsp70 binding (blue). We propose that substrate (purple) binding disrupts the JD-CTD interaction, exposing the JD and enabling the recruitment of Hsp70 to the substrate-activated DnaJB8 protein.

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UT Southwestern Medical Center

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