Epirubicin-Loaded Nanomedicines Beat Immune Checkpoint Blockade Resistance in Glioblastoma (IMAGE)
Caption
Left: Hydrophobic epirubisin is conjugated to one end of hydrophilic polyethylene glycol (PEG) chain with aspartate-hydrazide as a linker. In water, this molecule is self-assembled to form nano-micelles (Epi/m). Upper right: PTEN(+) or PTEN(-) GBM was transplanted into the brain of mice, and Epi/m and anti-PD1 antibody (aPD1) were administered through the tail vein to evaluate survival period. Bottom right: Comparison of survival period in case of PTEN(-)GBM. PBS (phosphate buffer solution) was administered to the control group. As a result, none of the control group (black) could survive more than 30 days (8/8). Epi/m alone group (pink) died gradually after 30 days, half (4/8) in 40 days, and 7/8 by 50 days. aPD1 alone (brown) killed 6/7 within 30 days. In contrast, using Epi/m+aPD1 (red), 1/8 died 50 days later, but 7/8 were alive after 3 months even.
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2020 Innovation Center of NanoMedicine
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