Figure 2: Suppression of Scale Melatonin-Synthesizing Enzyme in Space Flight (IMAGE)

Kanazawa University

Figure 2: Suppression of Scale Melatonin-Synthesizing Enzyme in Space Flight

Caption

(a) N-acetylserotonin O-methyltransferase (Asmt) mRNA expression levels in the regenerating scales during space flight in artificial gravity (F-1g) or microgravity (F-μg), and on the ground analyzed using real-time PCR. (b-e) mRNA expression levels of osteoclast-related factors: matrix metalloproteinase-9 (Mmp-9) (b), cathepsin K (Ctsk) (c), receptor activator of nuclear factor κβ ligand (Rankl) (d), and Calcitonin (e). F-1g, flight 1g; F-μg, flight microgravity; F-μg + Mel, F-μg treated with melatonin (1 μM). All targets were standardized to elongation factor 1 alpha expression levels and presented as relative ratios. All data are mean ± SEM (n = 4); *P < 0.05, **P < 0.01.

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Kanazawa University

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