Optical Maps of Drug Response of Mouse Hearts (IMAGE)
Caption
The mouse heart's response to two cardiovascular drugs. By bathing heart tissue in voltage-sensitive dyes that fluoresce with an intensity proportional to voltage scientists are able to map the duration of nerve impulses in the heart. These atrial maps correspond to untreated hearts (top), hearts perfused with the drug diazoxide (middle) and those treated with the drug pinacidil (bottom). The effect of the drugs was chamber specific: diazoxide decreased action-potential duration in the atria, but pinacidil had little effect on them.
Credit
Igor Efimov lab/WUSTL
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