Figure 4 (IMAGE) Kobe University Caption Transcriptional repression by promoting histone deacetylase 1 (HDAC1) affects the process from vascular endothelial cells to the production of hematopoietic stem cells (EHT). Erythroid/myeloid progenitor cells (EMP) in the yolk sac (Yolk sac) activate microglia and affect inflammation in the brain; pre-HSC in AGM differentiate in the bone marrow (BM); and the altered immune system affects the gut microbiota. Credit Figure derived from the paper published in Molecular Psychiatry (2022) (DOI：10.1038/s41380-022-01566-y) Usage Restrictions Credit must be given to the creator. License CC BY Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.