Figure 1. Endothelial Merlin plays a gatekeeping role in tip EC induction mediated through blocking VEGFR2 internalization at high VE-cadherin density (IMAGE)

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Figure 1. Endothelial Merlin plays a gatekeeping role in tip EC induction mediated through blocking VEGFR2 internalization at high VE-cadherin density

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Schematic diagram depicting roles of Merlin in different densities of VE-cadherin in each EC. Active Merlin forms a complex with VEGFR2 and VE-cadherin at relatively high VE-cadherin density, while inactive Merlin (S518) allows high VEGFR2 internalization in ECs with low VE-cadherin density, which leads to tip EC induction.

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