Figure 2. The changes of retinal vessels at postnatal day 6 after depletion of Merlin in ECs (IMAGE)
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When Merlin was depleted, tip cells and filopodia at the vascular front were enhanced, but cell proliferation was reduced compared with WT mice (Fig.2 A-B). Endothelial cell-specific molecule-1 (ESM-1), which is a tip cell marker, was increased in Merlin-depleted mice compared with WT mice (Fig.2 C).
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Institute for Basic Science
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