(IMAGE) Tokyo Medical and Dental University Caption Tau protein is incorporated into microglia by LRP1 cell surface receptor and then binds to PQBP1 to activate cGAS-STING pathway and expression of pro-inflammatory genes. Meanwhile, Tau binding to TREM2 activates other signal pathway. Credit Department of Neuropathology, TMDU Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.