Machine Action (IMAGE) Columbia University Caption An analysis of cryo-electron microscope images revealed that the enormous protein megalin (LRP2) changes shape. Credit A. Fitzpatrick, A. Beenken, L. Shapiro / Columbia's Zuckerman Institute Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. License CC BY-NC Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.