close-up details of zinc transporter structure (IMAGE)

DOE/Brookhaven National Laboratory

close-up details of zinc transporter structure

Caption

Detailed views of the ZIP protein structure in the zinc-blocking state. Metal binding sites (M1-3) show where zinc binds. The close-up view (c) shows how zinc binding to the M3 location—associated with two histidine residues (H151 and H149) on a flexible green loop portion of the protein—causes the loop to fold and block the exit of zinc from the pore of the protein.

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Brookhaven National Laboratory

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